Feb 4, 2013


The liver is a large, very important organ situated in the right upper quadrant of abdomen. The normal functions of the liver in the body are: 

To help store nutrients from food
To break down and remove harmful chemicals from the body
To build chemicals that the body needs to stay healthy.

Hepatoblastoma: The most common type of liver cancer in children is Hepatoblastoma. it occurs most frequently in infants or very young children between 2 months and 2 year.

  • Lump in the abdomen (most common)
  • Reduced appetite
  • lethargy
  • nausea / vomiting
  • Pain in abdomen
  • Jaundice
Investigations:The following minimal investigations are proposed to diagnose hepatoblastoma

  • Tumor markers- serum AFP
  • CT scan of abdomen with Ct guided FNAC or Biopsy
  • X-ray ches/CT Chest
  • Complete blood count
  • Biochem profile

Surgery & chemotherapy are two treatment options

Surgery: Liver resection according to the location & extent of the tumor. It will be either
  • Rt hepatectomy
  • Lt hepatectomy
  • Extended Rt or Lt hepatectomy
  • Bi or trisegmentectomy
If liver resection is not possible because of multicentric disease then liver transplant is the only treatment of option.

Chemotherapy is given before or after surgery. Surgery is done either as a sandwich surgery (in between cycles of chemotherapy) or it is done at the start & then chemotherapy is given.

The drugs used in chemotherapy are
  • Cisplatin
  • Doxorubicin
  • Vincristine
  • 5-Fluorouracil